• Vineet K Shrivastava, Thomas J Garite, Sheri M Jenkins, Lisa Saul, Pamela Rumney, Christine Preslicka, and Kenneth Chan.
• Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine, School of Medicine, Orange, CA, USA.
• Am. J. Obstet. Gynecol. 2009 Apr 1; 200 (4): 379.e1-6.

ObjectiveThe objective of the study was to compare intravenous normal saline with and without dextrose on the course of labor in nulliparae.Study DesignIn a double-blinded, controlled trial, term, nulliparae with singletons in active labor were randomized into 1 of 3 groups receiving either normal saline (NS), NS with 5% dextrose (D5NS), or NS with 10% dextrose (D10NS) at 125 mL/h. The primary outcome was total length of labor from onset of study fluid in vaginally delivered subjects. Maternal and neonatal outcomes were also analyzed.ResultsOf 300 subjects enrolled, 289 met inclusion criteria and completed the study. In vaginally delivered subjects, significant differences were noted in the second stage (P = .01) and total length of labor (P = .02). No significant differences were observed in the cesarean section rates between the groups (P = .21). No differences were noted in maternal or neonatal secondary outcomes.ConclusionAdministration of a dextrose solution, regardless of concentration, was associated with a shortened labor course in term vaginally delivered nulliparae subjects in active labor.

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