• Acta neurochirurgica · Jan 2012

    Chemokines as markers of local inflammation and angiogenesis in patients with chronic subdural hematoma: a prospective study.

    • Milo Stanisic, Staale Petter Lyngstadaas, Are Hugo Pripp, Ansgar Oddne Aasen, Karl-Fredrik Lindegaard, Jugoslav Ivanovic, Eivind Ilstad, Ane Konglund, Tiril Sandell, Omar Ellingsen, and Terje Saehle.
    • Department of Neurosurgery, Oslo University Hospital, Nydalen, Norway. mstanisi@ous-hf.no
    • Acta Neurochir (Wien). 2012 Jan 1; 154 (1): 113-20; discussion 120.

    ObjectiveThe goal of this study was to investigate the chemokines CCL2, CXCL8, CXCL9 and CXCL10 as markers of the inflammatory responses in chronic subdural hematoma (CSDH).MethodsSamples of peripheral venous blood and CSDH fluid (obtained during surgery) in 76 adult patients were prospectively analyzed. Chemokine values were assessed by a Multiplex antibody bead kit.ResultsWe found significantly higher levels of chemokines CCL2, CXCL8, CXCL9 and CXCL10 in hematoma fluid compared with serum.ConclusionsChemokines are elevated in the hematoma cavity of patients with CSDH. It is likely that these signaling modulators play an important role in promoting local inflammation. Furthermore, biological activity of CCL2 and CXCL8 may promote neovascularization within the outer CSDH membrane, and a compensatory angiostatic activity of CXCL9 and CXCL10 may contribute to repairing this disorder. This phenomenon was restricted to the hematoma site, and the systemic chemokine levels might not reflect local immune responses.

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