• Ned Tijdschr Geneeskd · Jan 2014

    Review

    [Cardiovascular and gastrointestinal safety of NSAIDs].

    • Patricia M L A van den Bemt, Eric T T L Tjwa, and Martijn G H van Oijen.
    • *Dit artikel is in iets gewijzigde vorm gepubliceerd in Pharmaceutisch Weekblad Wetenschappelijk Platform (Van den Bemt PMLA, Kuipers EJ, Tjwa ETTL. Cardiovasculaire en gastro-intestinale veiligheid van NSAID's. 2014;8:a1420).
    • Ned Tijdschr Geneeskd. 2014 Jan 1; 158: A7311.

    AbstractAll NSAIDs may induce cardiotoxicity. In this respect naproxen is relatively the safest choice. Selective cyclo-oxygenase-2-inhibitors (coxibs) are at least as effective in preventing clinically relevant gastrointestinal toxicity as non-selective NSAIDs plus a protonpump inhibitor (PPI). Non-selective NSAIDs plus a PPI are more effective in prevention of dyspepsia than coxibs. After a serious gastrointestinal complication while using NSAIDs, in principal the patient should no longer use NSAIDs. If needed, a coxib plus a PPI is the first choice.

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