-
Randomized Controlled Trial Comparative Study
Preemptive analgesia with midazolam and diclofenac for hernia repair pain.
- A Hasani, H Maloku, F Sallahu, V Gashi, and S U Ozgen.
- Department of Anesthesiology and Reanimation, University Clinical Centre of Kosovo, Prishtina, Kosovo. antigona.hasani@gmail.com
- Hernia. 2011 Jun 1; 15 (3): 267-72.
PurposeThe aim of this study was to compare the preemptive effects of systemic midazolam and diclofenac on postoperative analgesia when used before surgical incision.MethodsNinety patients, aged 35-65 years, scheduled for hernia repair surgery were included in the study. Forty five patients in the midazolam group (group M + D) received 0.05 mg/kg midazolam and 1.5 mg/kg diclofenac, 15 min before surgical incision; 45 patients in the diclofenac group (group D) received diclofenac without midazolam, 15 min before surgical incision. Postoperative pain (Verbal Rating Scale-6) score and first analgesic requirement were noted. Sedation levels were evaluated with Observer's Assessment of Alertness/Sedation (OAA/S) score. Adverse effects during and after the operation were also recorded.ResultsGroup M + D had a significantly lower proportion of patients who exhibited postoperative pain than group D (11.1% vs. 37.7%, respectively; P < 0.05). The VRS-6 score in group M + D was 1.4 (range 0-4), whereas the corresponding score in group D was 2.4 (range 1-6). Mean (OAA/S) score in group M + D was lower than in the group D (1.5 ± 0.3 vs. 3.3 ± 0.4, respectively; P < 0.05). Duration of sedation in group M + D was significantly longer than the corresponding mean for group D (22.5 ± 6.4 vs. 12.1 ± 3.3 min, respectively; P < 0.01). The first postoperative analgesic request after surgery was 120 min in group M + D and 60 min in group D (P < 0.05).ConclusionMidazolam enhances the postoperative analgesic effects of diclofenac when used before the onset of noxious stimuli.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.