This paper reports on the effect of orally administered flurbiprofen, a potent inhibitor of prostaglandin synthesis (cyclo oxygenase inhibitor), on the mechanical properties of traumatized rat tendo-achilles to see if the F2 alpha prostaglandin was affected and hence the repair process. The drug (1 mg) was administered daily for 7 days to 18 rats whose tendo-achilles were traumatized by crimping using a predetermined force (50 N) applied for 10s. ⋯ Forty non-traumatized, untreated rats were examined as controls. In vitro studies showed that there was no significant difference in the stress--strain and relaxation characteristics between the three groups and no histological differences were observed.
AbstractThis paper reports on the effect of orally administered flurbiprofen, a potent inhibitor of prostaglandin synthesis (cyclo oxygenase inhibitor), on the mechanical properties of traumatized rat tendo-achilles to see if the F2 alpha prostaglandin was affected and hence the repair process. The drug (1 mg) was administered daily for 7 days to 18 rats whose tendo-achilles were traumatized by crimping using a predetermined force (50 N) applied for 10s. Eighteen sham control rats were identically traumatized and given daily the same volume of liquid (water) not containing the drug. Forty non-traumatized, untreated rats were examined as controls. In vitro studies showed that there was no significant difference in the stress--strain and relaxation characteristics between the three groups and no histological differences were observed.