• Am J Hosp Palliat Care · Nov 2013

    Successful treatment by adding duloxetine to pregabalin for peripheral neuropathy induced by paclitaxel.

    • Motoyasu Takenaka, Hiroki Iida, Shigemi Matsumoto, Shinobu Yamaguchi, Noritaka Yoshimura, and Maki Miyamoto.
    • 1Department of Anesthesiology and Pain Medicine, Gifu University Graduate School of Medicine, Yanagido, Gifu City, Gifu, Japan.
    • Am J Hosp Palliat Care. 2013 Nov 1; 30 (7): 734-6.

    AbstractAlthough paclitaxel is a commonly used anticancer drug, peripheral neuropathy may develop as a side effect. Worsening of the symptoms with time may cause patients who receive paclitaxel to give up their chemotherapy. Duloxetine, a serotonin- and norepinephrine-reuptake inhibitor, has been used to treat peripheral neuropathic pain. We report the case of a 68-year-old man with gastric cancer, who underwent gastrectomy and then received 8 cycles of chemotherapy involving weekly administrations of paclitaxel. Under this paclitaxel treatment, he complained of severe peripheral neuropathy, leading to a diminished quality of life. Following treatment with a combination of duloxetine and pregabalin, a remission of his symptoms was achieved. Duloxetine plus pregabalin therapy may be useful for the peripheral neuropathy induced by paclitaxel.

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