• BMJ · Oct 1994

    Randomized Controlled Trial Comparative Study Clinical Trial

    n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis.

    • L March, L Irwig, J Schwarz, J Simpson, C Chock, and P Brooks.
    • Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, St Leonards, NSW, Australia.
    • BMJ. 1994 Oct 22; 309 (6961): 1041-5; discussion 1045-6.

    ObjectiveTo evaluate the efficacy of paracetamol and a non-steroidal anti-inflammatory drug for symptom relief in osteoarthritis.DesignDouble blind, randomised, controlled trials in individual patients (n of 1 trials). Three treatment cycles with two weeks' each of paracetamol (1 g twice daily) and diclofenac (50 mg twice daily) prepared in identical gelatin capsules.SettingGeneral practices in metropolitan Sydney, Australia.Subjects25 patients (median age 64 years) with pain of osteoarthritis (median duration of disease eight years) considered by their general practitioners to require regular treatment. 20 were already taking non-steroidal anti-inflammatory drugs.Main Outcome MeasuresDiary of pain and stiffness, function, and side effects.Results15 patients completed the study, five withdrew early but had made a therapeutic decision, and five dropped out very early. Results from 20 patients were analysed. Several patterns of response evolved. Eight of the 20 patients found no clear difference, symptoms being adequately controlled by paracetamol; five indicated a clear preference for the non-steroidal anti-inflammatory drug; two showed control of symptoms after their initial two weeks of the non-steroidal anti-inflammatory drug which continued throughout subsequent treatment changes; in five the non-steroidal anti-inflammatory drug may have been better but neither agent gave satisfactory control. After three months nine of the 20 patients had adequate symptom control with paracetamol alone.ConclusionsOf 1 studies--that is, randomised trials in individual patients--are clinically useful in deciding treatment in heterogeneous conditions which require long term symptomatic relief. In osteoarthritis many patients currently receiving or being considered for non-steroidal anti-inflammatory drugs may achieve adequate control with paracetamol.

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