• Bjarne Elholm, Klaus Larsen, Nete Hornnes, Finn Zierau, and Ulrik Becker.
• Alcohol Unit, Copenhagen University Hospital, Hvidovre, Capital Region, Copenhagen, Denmark.
• Alcohol Alcohol. 2011 May 1; 46 (3): 318-23.

AimsTo investigate whether, in the treatment with chlordiazepoxide for outpatient alcohol withdrawal, there are advantages of symptom-triggered self-medication over a fixed-schedule regimen.MethodsA randomized controlled trial in outpatient clinics for people suffering from alcohol dependence (AD) and alcohol-related problems; 165 adult patients in an outpatient setting in a specialized alcohol treatment unit were randomized 1:1 to either a symptom-triggered self-medication or tapered dose, using chlordiazepoxide. Alcohol withdrawal symptoms, amount of medication, duration of symptoms, time to relapse and patient satisfaction were measured. Patients assessed their symptoms using the Short Alcohol Withdrawal Scale (SAWS). Patient satisfaction was monitored by the Diabetes Treatment Satisfaction Questionnaire. We used the Well-Being Index and the European addiction severity index for the 1-year follow-up.ResultsWe found no differences in the quantity of medication consumed, time to relapse, well being or treatment satisfaction.ConclusionSymptom-triggered self-medication was as safe as fixed-schedule medication in treating outpatients with AD and mild to moderate symptoms of AWS. The SAWS is a powerful monitoring tool, because it is brief and permits the subject to log the withdrawal symptoms.

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