• T-L Appleyard, C H Mann, and K S Khan.
• Academic Department of Obstetrics and Gynaecology, Birmingham Women's Hospital, Edgbaston, Birmingham, UK. tlappleyard@doctors.org.uk
• BJOG. 2006 Jul 1; 113 (7): 749-57.

BackgroundGuidelines exist for the management of endometriosis. Validated and reliable appraisal tools exist to assess the quality of guidelines.ObjectivesTo systematically appraise the quality of guidelines for the management of pelvic pain associated with endometriosis.Search StrategyGuidelines were identified using a prospective protocol through a systematic search of MEDLINE (1951-2005), EMBASE (1974-2005), the Cochrane Library (2005, issue 2), known guideline websites and the World Wide Web.Selection CriteriaType of document: guideline, consensus statement, care protocol or healthcare technology assessment produced by national or international professional organisations and societies or governmental agencies; subject: management of pelvic pain associated with endometriosis.Data Collection And AnalysisTwo validated appraisal tools, Cluzeau and The Appraisal of Guidelines and Research and Evaluation (AGREE), were used to quantitatively assess the quality of guidelines. Areas evaluated included 'rigour of development', 'context and content' and 'application.'Main ResultsEight of 596 potentially relevant citations identified met our inclusion criteria. The Cluzeau instrument quality score were the following: rigour of development, 53% (range 5-65%); context and content, 69% (range 29-79%) and application 20% (range 0-20%). The application dimension achieved significantly lower quality scores (P = 0.026 versus rigour of development and P = 0.017 versus context and content). The AGREE instrument quality scores were the following: scope and purpose, 68% (range 17-89%); stakeholder involvement, 33% (range 13-63%); rigour of development, 49% (range 10-81%); clarity of presentation, 55% (range 42-67%); applicability, 14% (range 0-28%) and editorial independence, 28% (range 8-67%). The applicability domain achieved significantly lower quality scores (P = 0.001 versus scope and purpose and P = 0.009 versus rigour of development).Author's ConclusionsGuidelines for the management of pelvic pain associated with endometriosis do not comply with the recommendations for high-quality standards.

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