• Heart Lung · May 2015

    Observational Study

    Potential biomarkers for early diagnosis of acute aortic dissection.

    • Wen Peng, Zhenyu Peng, Xiangping Chai, Qingyi Zhu, Guifang Yang, Qin Zhao, and Shenghua Zhou.
    • Department of Emergency, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
    • Heart Lung. 2015 May 1; 44 (3): 205-8.

    ObjectiveThe purpose of this study was to identify biological markers for early diagnosis of acute aortic dissection (AAD).Methods76 patients presented to the emergency room with acute chest pain within 6 h of occurrence were recruited for this study, and AAD diagnosed by aortic CTA. Biomarkers were measured by ELISA. ROC curve and Pearson correlation analysis were used to evaluate the sensitivity and specificity to diagnosis of AAD.ResultsThe serum levels of α-SMA, smMHC, sELAF, PC1 and D-dimer were significantly higher in AAD patients than in other groups (P < 0.05). Significant correlations between smMHC, sELAF, PC1, and D-dimer level were observed in AAD. Any combination of two markers showed good sensitivity (94.29%) and specificity (85.37%).ConclusionsmMHC, sELAF, PC1, or D-dimer alone is a biomarker for early diagnosis of AAD, but the combination of these markers has significantly higher diagnostic value.Copyright © 2015 Elsevier Inc. All rights reserved.

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