• M Okada, K Yoshimura, A Kojima, H Hirose, N Okajima, H Takeda, I Kikuchi, H Tai, T Tokuda, and H Okano.
• Department of Internal Medicine II, Daisan Hospital, Jikei University School of Medicine.
• Nihon Kyobu Shikkan Gakkai Zasshi. 1993 Sep 1; 31 (9): 1170-5.

AbstractSwyer-James syndrome is considered to be a relatively uncommon disease entity presenting with unilateral hyperlucent lung due to hypoplasia of a pulmonary artery and bronchiectasis of the affected lung. Association of bronchogenic carcinoma with Swyer-James syndrome has not apparently been reported in any previous literature, except for one Japanese case. In the present paper, we describe a 48-year-old male individual, who developed poorly differentiated squamous cell carcinoma of the right upper lobe bronchus after he had been diagnosed to have Swyer-James syndrome with unilateral hyperradiancy of the left lung. It is suggested that the bronchial epithelium of the unaffected lung in Swyer-James syndrome is likely to be more exposed to extrinsic carcinogens than that of the affected, underventilated lung, hence resulting in a higher risk of developing bronchogenic carcinoma.

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