• Environ. Toxicol. Pharmacol. · Nov 2013

    Review

    Antiangiogenic effects of marine sponge derived compounds on cancer.

    • Kalimuthu Senthilkumar, Jayachandran Venkatesan, Panchanathan Manivasagan, and Se-Kwon Kim.
    • Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan, 608-737, Republic of Korea.
    • Environ. Toxicol. Pharmacol. 2013 Nov 1; 36 (3): 1097-108.

    AbstractThe term "angiogenic switch" refers to a time-restricted event during tumor progression where the balance between pro- and anti-angiogenic factors, resulting in the transition from dormant avascularized hyperplasia to outgrowing vascularized tumor and eventually to malignant tumor progression. Targeting angiogenesis and its mechanistic pathways are critical target for cancer therapy. Recently, marine derived compounds, plays major role in cancer research. Several sponge derived compounds such as alkaloids, terpenes, macrocylic lactone and polyketide are leading drugs in the treatment of different types of diseases including cancer. Those marine sponge compounds inhibit cancer cell proliferation and tumor angiogenesis. Hence, this review sheds light on angiogenic regulators and marine sponge derived antiangiogenic compounds for cancer.Copyright © 2013 Elsevier B.V. All rights reserved.

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