• Ann Behav Med · Oct 2011

    C-reactive protein and pain sensitivity: findings from female twins.

    • Niloofar Afari, Sheeva Mostoufi, Carolyn Noonan, Brian Poeschla, Annemarie Succop, Laura Chopko, and Eric Strachan.
    • Department of Psychiatry, University of California-San Diego and VA San Diego Healthcare System, 9500 Gilman Drive, La Jolla, CA 92093, USA. nafari@ucsd.edu
    • Ann Behav Med. 2011 Oct 1; 42 (2): 277-83.

    BackgroundSystemic inflammation and pain sensitivity may contribute to the development and maintenance of chronic pain conditions.PurposeWe examined the relationship between systemic inflammation as measured by C-reactive protein (CRP) and cold pain sensitivity in 198 female twins from the University of Washington Twin Registry. We also explored the potential role of familial factors in this relationship.MethodsLinear regression modeling with generalized estimating equations examined the overall and within-pair associations.ResultsHigher levels of CRP were associated with higher pain sensitivity ratings at pain threshold (p = 0.02) and tolerance (p = 0.03) after adjusting for age, body mass index, time to reach pain threshold or tolerance, and clinical pain status. The magnitude of the associations remained the same in within-pair analyses controlling for familial factors.ConclusionsThe link between CRP and pain sensitivity may be due to non-shared environmental factors. CRP and pain sensitivity can be examined as potential biomarkers for chronic pain and other inflammatory conditions.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…