• C R Lammers, J L Rosner, D E Crockett, R Chhokra, and J G Brock-Utne.
• Department of Anesthesia, Stanford University Medical Center, Stanford, CA 94305-5640, USA.
• Paediatr Anaesth. 2002 Jan 1; 12 (1): 26-8.

BackgroundThe aim of the study was to see whether sodium citrate solution would speed the gastric absorption of oral midazolam.MethodsForty presurgical ASA I and II patients (aged 2-6 years) were randomly assigned to one of two groups. Group I received midazolam 0.5 mg x kg(-1) mixed with sodium citrate while group II (control) received midazolam 0.5 mg x kg(-1) mixed with Hawaiian fruit punch.ResultsThere was no statistical difference between the ages, weights, preoperative sedation and anxiety scores in the two groups. After premedication, the onset of sedation (mean +/- SD) measured by the first change in sedation score was found to be significantly faster (P < 0.05) in group I (17.8 +/- 7.11) compared with group II (21.9 +/- 5.34). There was no statistical difference in anxiety at any time intervals, separation or induction scoring for both groups. Gastric volumes and the pH of gastric aspirates between the two groups were not statistically significant.ConclusionsThe time to onset of sedation can potentially be shortened, by using a preparation of intravenous midazolam and antacid, given orally.

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