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Australian dental journal · Dec 2005
ReviewA concise review of the basic biology and pharmacology of local analgesia.
- S Subramaniam and M Tennant.
- Centre for Rural and Remote Oral Health, The University of Western Australia.
- Aust Dent J. 2005 Dec 1; 50 (4 Suppl 2): S23-30.
AbstractLocal analgesics are the most commonly used group drugs in dental practice. However, due to their frequent use and high margin of safety, often dental practitioners neglect to properly understand the biology and pharmacology of these drugs. This article reviews the basic concepts of pain, pain pathways, the mode of action of local analgesics and factors which affect their usage. Specific details and properties of some currently available solutions are also outlined. A greater understanding of the biology and pharmacology of local anaesthetics will ultimately lead to safer and more effective use in everyday clinical practice.
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