• L Herregods, G Rolly, E Mortier, M Bogaert, and C Mergaert.
• Department of Anesthesiology, State University of Ghent, University Hospital, Belgium.
• Int J Clin Monit Comput. 1989 Apr 1; 6 (2): 67-73.

AbstractPropofol has been used as IV induction (2 mg/kg) and maintenance agent (150 micrograms/kg/min and 100 micrograms/kg/min after 30 min), combined with N2O/O2 in 16 premedicated (atropine 0.5 mg, Thalamonal 2 ml IM) and mechanically ventilated patients, having ear surgery or arthroscopy. Cranial biopotentials were analysed by 2 different techniques: 1. The Anesthesia and Brain Activity Monitor (ABM Datex) providing the zero crossing frequency (ZXF) as a value for the mean frequency of the EEG signal during a considered time interval, the mean integrated voltage (MIV) as a mean value of the amplitude of the same EEG signal and the spontaneous electromyography of the frontal muscle (SEMG). 2. The EEG trend monitor (rough signal, spectral analysis (S.A.), procentual display). The EEG changes, recorded during propofol anesthesia, are comparable with both techniques. Induction is characterised by a decrease in ZXF, caused by a procentual increase in the low frequency bands (the delta band represents more than 80% of the total power). During the perfusion period an increase in the power of the alpha band (10% to 40%) and a decrease in the delta band is noticed. The ZXF regains its original value. At the end of the procedure the ZXF increases (beta band to more than 30%). A correlation was looked for between the EEG changes and the propofol blood concentrations. The higher the propofol blood concentrations, the more pronounced the low frequency bands. The appearance of beta waves or a ZXF greater than 10 Hz indicates pending arrousal.

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