• Minerva medica · Dec 2008

    Review Case Reports

    [The combination acetominophen/tramadol in hematological daily practice].

    • F Cavazzini.
    • Sezione di Ematologia, Dipartimento di Scienze Biomediche e Terapie Avanzate, Azienda Ospedaliera-Universitaria Arcispedale S. Anna, Ferrara, Italy. cvzfnc@unife.it
    • Minerva Med. 2008 Dec 1; 99 (6): 631-41.

    AbstractThe combination acetominophen/tramadol implies the use of two molecules which are different in the pharmacological structure but share a biological similarity in kinetics. Their respective actions are directed to different components of the nociceptive afference. Hematological clinical practice daily challenges diseases in with pain may be a very important symptom, ranging from acute leukemia to the common effects of certain chemotherapy regimens. Multiple myeloma gives one of the best example of a disease in which pain can be inflammatory (the compression of a nerve root) or neuropathic (demyelinating process) in origin. The use of acetaminophen/tramadol combination in the common ward or outward activity with myeloma patients indicates how it is possible to reach a good control of chronic pain with a minimum overlapping of the toxicities related to the primary disease as well as to the specific treatment. Furthermore, acetaminophen/tramadol combination is extremely useful also in those clinical situations in which a short term pain control is needed, particularly for the optimal safety profile.

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