• Lorraine C Als, Anna Tennant, Simon Nadel, Mehrengise Cooper, Christine M Pierce, and M Elena Garralda.
• 1Centre for Mental Health, Department of Medicine, Imperial College London, London, United Kingdom. 2Department of Paediatric Intensive Care, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom. 3Department of Paediatric Intensive Care, Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
• Crit. Care Med. 2015 Aug 1;43(8):e312-5.

ObjectiveTo study 12-month persistence of neuropsychological deficits in PICU survivors.DesignProspective follow-up study.SettingTwo PICUs.ParticipantsChildren 5-16 years old with neuropsychological deficits 3-6 months following PICU care for meningoencephalitis, sepsis, and other critical illnesses (excluding other primary neurological disorders).InterventionsNone.Measurements And Main ResultsNeuropsychological function was assessed using the Cambridge Neuropsychological Test Automated Battery, the Children's Memory Scale, and the Wechsler Abbreviated Scale of Intelligence or Wide Range Intelligence Test. Forty-seven of 88 PICU admitted children (53%) were identified as neuropsychologically impaired 3-6 months after discharge; of these, 23 provided 12-month follow-up data. In spite of significant improvements in measures of memory, there was little change in intelligence quotient and visual attention over the study period, and children's educational progress remained below expectation.ConclusionsWe found persistently reduced neuropsychological function following PICU admission in the critical illnesses under study.

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