• Yong-Hong Zhang, Yan Zhao, Ning Li, Yan-Chun Peng, Eleni Giannoulatou, Rong-Hua Jin, Hui-Ping Yan, Hao Wu, Jin-Hua Liu, Ning Liu, Da-Yan Wang, Yue-Long Shu, Ling-Pei Ho, Paul Kellam, Andrew McMichael, and Tao Dong.
• Beijing You'an Hospital, Capital Medical University, Beijing PO 100069, China.
• Nat Commun. 2013 Jan 1; 4: 1418.

AbstractThe SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C is much more common in Han Chinese. Here we report that the CC genotype is found in 69% of Chinese patients with severe pandemic influenza A H1N1/09 virus infection compared with 25% in those with mild infection. Specifically, the CC genotype was estimated to confer a sixfold greater risk for severe infection than the CT and TT genotypes. More importantly, because the risk genotype occurs with such a high frequency, its effect translates to a large population-attributable risk of 54.3% for severe infection in the Chinese population studied compared with 5.4% in Northern Europeans. Interferon-induced transmembrane protein-3 genetic variants could, therefore, have a strong effect of the epidemiology of influenza in China and in people of Chinese descent.

40 keywords...

hide…