• J Yang, B Wang, H-X Zhou, B-M Liang, H Chen, C-L Ma, J Xiao, J Deng, L Yan, Y-P Chen, C-L Chen, F Chen, X-M Ou, and Y-L Feng.
• Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
• Int. J. Tuberc. Lung Dis. 2014 Nov 1; 18 (11): 1378-84.

SettingGenetic predisposition, in addition to smoking, is known to play a key role in susceptibility to chronic obstructive pulmonary disease (COPD). Several candidate genes have been proposed for COPD, including surfactant protein B (SFTPB). However, large studies in populations with different ethnic backgrounds and environments are required to clarify the role of SFTPB in COPD.ObjectiveWe investigated the association of SFTPB polymorphisms with COPD susceptibility and lung function in a Chinese Han population.DesignFour single nucleotide polymorphisms (SNPs) in the SFTPB gene were genotyped in 680 COPD patients and 687 controls. Allele frequencies and genotype distributions were compared between cases and controls and the potential relationships between these SNPs and lung function were investigated. Associations between haplotypes and COPD susceptibility were also assessed.ResultsThe SFTPB exon polymorphism rs1130866 significantly protected subjects from COPD (adjusted P = 0.004) and was associated with an increase in forced expiratory volume in 1 s (FEV(1)) (adjusted P = 0.014).ConclusionsSFTPB variants are associated with COPD susceptibility and lung function in the Chinese Han population.

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