• Tuncay Yetgin, Olivier C Manintveld, Fahriye Groen, Buket Tas, Arie P Kappetein, Robert-Jan van Geuns, Felix Zijlstra, and Dirk J Duncker.
• Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
• Cardiol Rev. 2012 Nov 1; 20 (6): 279-87.

AbstractRemote ischemic conditioning (RIC) is an intervention, in which intermittent episodes of ischemia and reperfusion in an organ or tissue distant from the target organ requiring protection, provide armour against lethal ischemia-reperfusion injury. Although the exact mechanisms underlying the protection mediated through RIC have not been clearly established, the release of humoral factors and the activation of neural pathways have been implicated. There is now clinical evidence suggesting that this form of protection can be induced by a simple, noninvasive, and cost-effective procedure such as inflation and deflation of a blood pressure cuff and that this intervention provides increased organ protection in a variety of clinical scenarios, for example, in myocardial infarction. Here we provide an overview of the history and evolution of RIC, the potential mechanisms underlying its protective effects, and published randomized clinical trials in cardiovascular procedures.

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