• Neurobiology of aging · Aug 2011

    No replication of genetic association between candidate polymorphisms and Alzheimer's disease.

    • Emmanuelle Cousin, Sandrine Macé, Corinne Rocher, Colette Dib, Gaëlle Muzard, Didier Hannequin, Laurent Pradier, Jean-François Deleuze, Emmanuelle Génin, Alexis Brice, and Dominique Campion.
    • Biological Sciences Department, sanofi-aventis Recherche et Développement, Centre de Génétique humaine, 91057 Evry, France.
    • Neurobiol. Aging. 2011 Aug 1; 32 (8): 1443-51.

    AbstractAlzheimer's disease is a genetically complex disorder, for which new putative susceptibility genes are constantly proposed in the literature. We selected 16 candidate genes involved in biological pathways closely related to the pathology, and for which a genetic association with Alzheimer's disease was previously detected: ACE, BACE1, BDNF, ECE1, HSPG2, IDE, IL1a, IL6, IL10, MAPT, PLAU, PrnP, PSEN1, SORL1, TFCP2 and TGFb1. The variants originally associated with the disease were genotyped in a French Caucasian sample including 428 cases and 475 controls and tested for association in order to replicate the initial results. Despite a careful replication study design, we failed to validate the initial findings for any of these variants, with the possible exception of MAPT, SORL1 and TFCP2 for which some nominal but inconsistent evidence of association was observed.Copyright © 2009 Elsevier Inc. All rights reserved.

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