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Antimicrob. Agents Chemother. · Oct 2012
Antibacterial activities of iron chelators against common nosocomial pathogens.
- Mitchell G Thompson, Brendan W Corey, Yuanzheng Si, David W Craft, and Daniel V Zurawski.
- Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
- Antimicrob. Agents Chemother. 2012 Oct 1; 56 (10): 5419-21.
AbstractThe activities of iron chelators (deferoxamine, deferiprone, Apo6619, and VK28) were evaluated against type strains of Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. Deferiprone, Apo6619, and VK28 each inhibited growth in standard and RPMI tissue culture medium, while deferoxamine had no effect. Additionally, time-kill assays revealed that VK28 had a bacteriostatic effect against S. aureus. Therefore, these newly developed iron chelators might provide a nontraditional approach for treatment of bacterial infections.
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