• Dae-Young Kim, Jee Hyun Kim, Young Joo Park, Kyung Hae Jung, Hee Sun Chung, Soo Shin, Sung-Soo Yun, Seonyang Park, and Byoung Kook Kim.
• Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong, Jongro-gu, 110-744, Seoul, Korea.
• Ann. Hematol. 2004 May 1; 83 (5): 309-12.

AbstractWe describe a 55-year-old woman who presented with pancytopenia with a normocytic and normochromic anemia which was progressive despite conventional treatments such as folic acid, vitamin B6, and oxymetholone. Her physical findings and history of a previous massive postpartum hemorrhage suggested Sheehan's syndrome, and the pituitary hormonal studies revealed panhypopituitarism. After 4 months of thyroxine and glucocorticoid replacement therapy, her pancytopenia and bone marrow hypoplasia recovered completely. Pancytopenia is a rare manifestation of a hormonal abnormality, but hematologists need to be aware of panhypopituitarism as a differential diagnosis when women showing features of hypopituitarism present with pancytopenia because it can be reversed with adequate hormone replacement.

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