• Jinquan Ji, Gang Wang, Ke Sun, Guobin Zhou, Zhipeng Wang, and Yan Wang.
• Department of Anesthesiology, ZHOU Guobin,WANG zhipeng WANG Yan, Guangdong General Hospital , Guangzhou 510080, China.E-mail: 5413jjq@sina.com.
• Nan Fang Yi Ke Da Xue Xue Bao. 2015 Feb 1; 35 (2): 264-7.

ObjectiveThis clinical study was conducted to investigate the effects of dexmedetomidine (DEX) combined with propofol on vital signs and anaesthetic depth in patients.MethodsNinety patients with ASA 1-2 requiring painless colonoscopy for colonic polyps resection were randomized to receive DEX 0.3 micro;g/kg (group D, n=45) followed by propofol 1 mg/kg or propofol 2 mg/kg (group C, n=45), and according to the body activity and operation time, additional doses of propofol (0.2-0.5 mg/kg) were given. The full recovery time, operation time, consumed dose of propofol, mean arterial pressure (MAP), heart rate (HR), hemoglobin oxygen saturation levels(SPO₂) and NTI were recorded.ResultsThe SPO₂recover time and the consumed dose of propofol in group D were decreased compared to those in group C (P<0.01). The rate of the body activity in group D was lower than that in group C (P<0.05). The NTI in group C was lower than that in group D (P<0.05). The HR and MAP were similar in both groups.ConclusionUnder Narcotrend monitoring, the value of DEX combined with low dose of propofol in colonoscopy for colonic polyps resection is to reach more reasonable depth of anesthesia to reduce adverse responses and the dose of propofol.

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