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- Turgut Durduran, Chao Zhou, Brian L Edlow, Guoqiang Yu, Regine Choe, Meeri N Kim, Brett L Cucchiara, Mary E Putt, Qaisar Shah, Scott E Kasner, Joel H Greenberg, Arjun G Yodh, and John A Detre.
- Departments of Radiology, University of Pennsylvania, PA, USA. durduran@alumni.upenn.edu
- Opt Express. 2009 Mar 2; 17 (5): 3884-902.
Abstract"Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30 degrees , 15 degrees , 0 degrees , -5 degrees and 0 degrees angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO(2)) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.
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