• Wei Wang, Weimin Wang, Xiaofei Guo, Yanjun Zeng, and Xiaodan Jiang.
• Neurosurgery Institute of Guangdong, Southern Medical University, Beijing, China. gzwangwm@163.com
• Epileptic Disord. 2009 Dec 1; 11 (4): 333-8.

PurposeTo present a case of small hypothalamic hamartoma (HH) causing gelastic seizures and treated with stereotactic radiofrequency thermocoagulation.Case ReportA 22-year-old man presented with intractable gelastic seizures and focal seizures refractory to medical treatment. Magnetic resonance imaging showed a 6 mm x 6 mm x 7 mm sessile intraventricular HH. Under local anesthesia, four intra-hamartoma lesions were made via stereotactic radiofrequency thermocoagulation using a depth electrode for recording and stimulation.ResultsTransient central hyperthermia, hypertension, and tachycardia were observed during the coagulation procedure. Intra-hamartoma spikes and slow waves were identified on depth electrode recordings. No gelastic seizure was induced by deep stimulation. The patient was seizure-free during the 12-month follow up and no permanent surgical complications occurred.ConclusionStereotactic radiofrequency thermocoagulation may be an effective and safe treatment option in selected cases of hypothalamic hamartoma with gelastic seizures.

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