• Trends in microbiology · Dec 2005

    Review

    Staphylococcal innate immune evasion.

    • Suzan H M Rooijakkers, Kok P M van Kessel, and Jos A G van Strijp.
    • Eijkman Winkler Institute, UMC Utrecht G04-614, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
    • Trends Microbiol. 2005 Dec 1; 13 (12): 596-601.

    AbstractUpon entering the human body, bacteria are confronted with the sophisticated innate defense mechanisms of the human host. From work in recent years it has become obvious that a new and growing family of small and excreted proteins can counteract the antibacterial effects of innate immunity. These highly selective proteins pick out crucial elements of our immune system and inhibit their function. In Staphylococcus aureus these proteins act on specific cellular receptors, on antimicrobial peptides and especially on the complement system. The combined action of this growing group of essential virulence factors ascertains efficient innate immune evasion.

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