• Neurology · Jan 1998

    Case Reports

    Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome.

    • L Rosin, P DeCamilli, M Butler, M Solimena, H P Schmitt, N Morgenthaler, and H M Meinck.
    • Department of Neurology, University of Heidelberg, Germany.
    • Neurology. 1998 Jan 1; 50 (1): 94-8.

    AbstractWe report a patient who developed stiff-man syndrome, including disabling shoulder subluxation and wrist ankylosis, in association with breast cancer. Immunologic investigations disclosed autoimmunity directed against not only glutamic acid decarboxylase but also amphiphysin, a 128-kd protein located in the presynaptic compartment of neurons. The patient improved after surgery and corticosteroid treatment and has been stable for nearly 4 years on only anti-estrogenics. The triad of stiff-man syndrome, breast cancer, and autoantibodies against amphiphysin identifies a new autoimmune paraneoplastic syndrome of the CNS.

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