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- M Kadosaki, K Enzan, T Horiguchi, H Komatsu, and M Suzuki.
- Department of Anesthesiology, Akita University School of Medicine.
- Masui. 1993 Jun 1; 42 (6): 906-9.
AbstractWe studied neuromuscular blocking effects of isoflurane using a neuromuscular transmission monitor in three myasthenia gravis patients. Severity of myasthenia gravis was different among three patients. T1 decreased by 12% in a mild case (I type), by 18% in a moderate case (IIa type) and by 42% in severe case (III type) during isoflurane anesthesia. Also, TOF ratio decreased by 12% in a mild case, by 22% in a moderate case, and 48% in a severe case during isoflurane anesthesia. We conclude that in patients with more severe myasthenia gravis, neuromuscular blocking effect of isoflurane is more potentiated.
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