• Y Shir, Z Shenkman, V Shavelson, E M Davidson, and G Rosen.
• Department of Anesthesiology, CCM and Pain Treatment Service, Hadassah University Hospital, Jerusalem, Israel.
• Clin J Pain. 1998 Dec 1; 14 (4): 350-3.

ObjectivePain relief is still inadequate in many hospitalized patients, especially children in whom suboptimal use of analgesic drugs is still common. In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications.SettingTertiary university hospital.PatientsOf the 70 children treated thus far with oral methadone, five are described in the present report.Main Outcome MeasurePain relief, acceptability, and side effects of oral methadone in children with pain.ResultsTreatment with oral methadone (0.1% in 10% glucose, dose range of 0.2-0.6 mg/kg/day) for time periods of up to 6 weeks resulted in a rapid onset and stable pain relief, with no major side effects. No adverse responses were encountered after discontinuation of treatment. In three of the children, a parent-controlled analgesia regimen was successfully employed.ConclusionsOral methadone can be recommended for babies and children who have severe pain that is not alleviated by nonopioid medications and who are capable of oral intake.

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