• John W Warren, Vadim Morozov, and Fred M Howard.
• Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
• Am. J. Obstet. Gynecol. 2011 Sep 1; 205 (3): 199.e1-5.

AbstractThe cause of noncyclical chronic pelvic pain (CPP) in many women is unknown: 30% have no identifiable pelvic pathology, and in those who do the relationship of CPP and the pathology is often unclear. Moreover, epidemiologic studies demonstrate that the common findings of endometriosis and adhesions do not greatly increase the odds of having CPP. CPP and the functional somatic syndromes (fibromyalgia, irritable bowel syndrome, and others) share many characteristics including pain as a prominent symptom and comorbidity. For the functional somatic syndromes, the initial focus of etiologic investigations has been on local mechanisms and then on systemic pathogeneses. We believe that the research trajectories of the functional somatic syndromes and CPP are converging. Their juncture might reveal an important pathologic mechanism for CPP in some women that is primarily outside the pelvis. This observation would open up new areas of exploration and treatment of CPP.Copyright © 2011 Mosby, Inc. All rights reserved.

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