• R A Berg, D Wilcoxson, R W Hilwig, K B Kern, A B Sanders, C W Otto, D K Eklund, and G A Ewy.
• Department of Pediatrics, College of Agriculture, University of Arizona, Tucson, USA.
• Ann Emerg Med. 1995 Sep 1; 26 (3): 342-50.

Study ObjectiveTo compare CPR with chest compressions plus ventilatory support (CC+V) and chest compressions alone (CC).DesignProspective, randomized study.SettingResearch laboratory.InterventionsAfter 2 minutes of ventricular fibrillation, 18 domestic swine (20 to 35 kg) were treated first with CC or CC+V for 10 minutes, then with standard advanced cardiac life support.ResultsHemodynamics, survival, and neurologic outcome were determined. All 8 swine subjected to CC+V and all 10 subjected to CC showed return of spontaneous circulation. One animal in each group died within 1 hour. Seven of 8 animals in the CC+V group survived for 24 and 48 hours, compared with 9 of 10 CC animals at 24 hours and 8 of 10 at 48 hours. All 48-hour survivors were neurologically normal.ConclusionIn this experimental model of bystander CPR, we could not detect a difference in hemodynamics, 48-hour survival, or neurologic outcome when CPR was applied with and without ventilatory support.

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