• Anesthesia and analgesia · Jun 1983

    Lack of arrhythmogenicity of isoflurane following administration of aminophylline in dogs.

    • J A Stirt, J M Berger, and S F Sullivan.
    • Anesth. Analg. 1983 Jun 1; 62 (6): 568-71.

    AbstractInduction of halothane anesthesia after aminophylline administration may cause ventricular arrhythmias. Isoflurane may be as effective a bronchodilator as halothane. This study was designed to determine whether induction of isoflurane anesthesia after intravenous aminophylline is arrhythmogenic in dogs. One group of six dogs was anesthetized with 1.5% isoflurane in the absence of aminophylline. Three additional groups of six dogs were given intravenous aminophylline 10, 25, or 50 mg/kg, respectively, followed 3 min later by 1.5% isoflurane. No arrhythmias occurred after aminophylline and isoflurane at any time in any animal. In contrast to halothane, induction of isoflurane anesthesia after aminophylline is safe and does not cause cardiac arrhythmias.

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