• Clinical therapeutics · Jan 1981

    Comparative Study Clinical Trial Controlled Clinical Trial

    Comparative trial of intravenous lorazepam and clonazepam im status epilepticus.

    • L Sorel, L Mechler, and J Harmant.
    • Clin Ther. 1981 Jan 1; 4 (4): 326-36.

    AbstractThe primary use of lorazepam, when administered intravenously (IV), has been in the treatment of acute attacks of anxiety and agitation. Recent studies have investigated its efficacy in patients with status epilepticus. The present study compared the efficacy and tolerability of lorazepam and clonazepam in the treatment of status epilepticus. Lorazepam, 4 to 10 mg IV, and/or clonazepam, 1 mg IV, was administered in 61 hospitalized epileptic patients. If needed, the dose of each agent was repeated in 20 minutes. Twenty-two patients were given lorazepam, nine were given clonazepam, and 30 were given both drugs at different times. Improvement in EEG was greater with lorazepam while the clinical symptoms responded more completely to clonazepam. Both drugs were most effective in patients with secondary generalized epilepsy. Drowsiness followed either drug. Psychomotor agitation followed either drug in 12% of patients.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.