• Gabriel Dumitrescu, Anna Januszkiewicz, Anna Ågren, Maria Magnusson, Bengt Isaksson, and Jan Wernerman.
• Department of Anaesthesia and Intensive Care Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. Electronic address: gabriel.dumitrescu@karolinska.se.
• Thromb. Res. 2015 Aug 1; 136 (2): 402-7.

IntroductionAfter major liver surgery, there are risks of both postoperative bleeding and thrombosis. Routine coagulation monitoring is indicated, but may not provide adequate clinical guidance. Thus, we described the clotting status in a pilot study using broader coagulation testing. We analysed the temporal pattern of coagulation tests to assess whether thromboelastometry (ROTEM®) would improve the quality of the postoperative monitoring of the coagulation status in patients undergoing major hepatic resections.Material And MethodsSixteen patients undergoing major liver resections were examined prior to surgery, on postoperative day 1, and subsequently, every three postoperative days during hospitalization. At the same time, the clinical signs of bleeding and thrombotic complications were monitored.ResultsOn postoperative day 1, increases in bilirubin, PT-INR, APTT, and D-dimers were observed, together with concomitant decreases in fibrinogen, platelet count, antithrombin (AT), protein C and protein S compared to preoperative values. On postoperative days 4 and 7, all of the variables had returned to the normal range except for D-dimers, AT and protein C. The ROTEM® median values remained within the normal range. There were no significant episodes of postoperative bleeding. Two patients were diagnosed with a pulmonary embolism.ConclusionDespite the abnormalities observed in routine coagulation monitoring, thromboelastometry indicated a balanced coagulation status following major hepatic surgery. The levels of both pro- and anticoagulant proteins changed over time during this period. The exact clinical role for thromboelastometry in major hepatic surgery remains to be established.Copyright © 2015. Published by Elsevier Ltd.

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