• Carlos F Santos, Adriana M Calvo, Vivien T Sakai, Thiago J Dionísio, José R P Lauris, Roberta M Carvalho, and Alceu S Trindade.
• Discipline of Pharmacology, Bauru School of Dentistry, University of São Paulo, São Paulo, Brazil. cebola@usp.br
• Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Oct 1; 102 (4): e16-20.

ObjectiveThis work aimed at performing a retrospective and comparative investigation of pharmacological therapeutic approach for pain and inflammation control for cleft lip and/or palate repair.Study DesignMedical charts from 2000 patients who underwent surgical procedures at the Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC-USP), Brazil, were assessed to obtain information regarding type of cleft, surgical procedure, and analgesic and anti-inflammatory drugs prescribed. The first 1000 consecutive surgeries performed in 1992 and 2002 were assessed.ResultsDifferent analgesic and anti-inflammatory agents-nonsteroidal anti-inflammatory drugs (NSAIDS), steroids, and opioids-were given to patients perioperatively and postoperatively. NSAIDS were given to almost all patients (97.03% in 1992 and 99.88% in 2002, P > .05). Steroid administration increased in 2002 (8.66% versus 17.71%, P < .05). Opioids were administered only in 2002 (50.31%, P < .05).ConclusionNSAIDS, steroids, and opioids were used for pain and inflammation control in cleft lip and palate repair at HRAC-USP. A change in the pattern of analgesic and anti-inflammatory drug use was observed when comparing 1992 and 2002. More potent compounds, such as opioids, were used in 2002 in a significant percentage of all the surgical procedures.

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