• A J Nordin, H Mäkisalo, and K A Höckerstedt.
• Fourth Department of Surgery, Helsinki University Hospital, Finland.
• Eur J Surg. 1996 Dec 1; 162 (12): 973-9.

ObjectiveTo evaluate the effects of dobutamine on peripheral and hepatic tissue oxygen tensions during the treatment of haemorrhagic shock.DesignRandomised, controlled trial.SettingUniversity hospital, Finland.Subjects12 Piglets, weight 20 kg.InterventionsHaemorrhagic shock (40% of blood volume removed) and resuscitation with crystalloid solution. Dobutamine infused (6.5 micrograms/kg/min) during resuscitation in 6 animals and 6 served as controls.Main Outcome MeasuresHaemodynamic and systemic oxygen transport variables. Hepatic, subcutaneous, transcutaneous, and conjunctival oxygen tensions measured continuously with polarographic electrodes.ResultsAll values decreased significantly during bleeding. Resuscitation restored the mean arterial pressure in both groups, and cardiac output exceeded the baseline by 24% in the dobutamine group (p < 0.05 compared with control). There was no difference in oxygen delivery and consequently tissue oxygen tensions remained at the control level in the dobutamine group.ConclusionsDobutamine infusion did not improve tissue oxygenation when used in addition to crystalloids to treat hypovolaemic shock.

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