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Neuroscience letters · Nov 1996
Local application of anti-NGF blocks the collateral sprouting in rats following chronic constriction injury of the sciatic nerve.
- L S Ro, S T Chen, L M Tang, and H S Chang.
- Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
- Neurosci. Lett. 1996 Nov 1; 218 (2): 87-90.
AbstractSystemic administration of anti-nerve growth factor (NGF) antibodies can block nociceptive fiber sprouting into denervated adult rat skin. However, the effect of local application of anti-NGF on collateral sprouting in rats caused by chronic constriction injury (CCI) has not been well studied. We investigated the influence of local anti-NGF on collateral sprouting caused by CCI of the rat's sciatic nerve. Using a dye-labeled plasma extravasation technique, we can easily evaluate the extent of collateral sprouting by the clearly defined blue coloration area. Our results showed that local application of anti-NGF either in a high or low dose significantly prevented the spread of collateral sprouting from the saphenous nerve into the sciatic innervation territory. In contrast, distilled water did not show a significant block of the saphenous nerve collateral sprouting. Our study suggests that collateral sprouting is dependent on the local availability of NGF by the nearby intact cutaneous nerve fibers.
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