• Ann Acad Med Singap · Nov 1994

    Review

    Update on newer neuromuscular blocking drugs.

    • H Holm and D Ostergaard.
    • Department of Anaesthesiology, Gentofte Hospital, University of Copenhagen, Denmark.
    • Ann Acad Med Singap. 1994 Nov 1; 23 (6 Suppl): 108-13.

    AbstractThe development of new non-depolarizing neuromuscular blocking drugs starting with the introduction of the intermediate-acting agents atracurium and vecuronium has made it possible to avoid the use of succinylcholine for elective cases. Recently 4 new drugs have become available; the short-acting mivacurium, the intermediate-acting rocuronium and the 2 long-acting drugs doxacurium and pipecuronium. The pharmacokinetic and pharmacodynamic profile of these drugs are reviewed in this paper.

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