• Marloes J Huijbers, Philip Spinhoven, Jan Spijker, Henricus G Ruhé, Digna J F van Schaik, Patricia van Oppen, Willem A Nolen, Johan Ormel, Willem Kuyken, Gert Jan van der Wilt, Marc B J Blom, Aart H Schene, A Rogier T Donders, and Anne E M Speckens.
• Department of Psychiatry, Radboud University Medical Center, Reinier Postlaan 10, 6525 GC Nijmegen, The Netherlands. Electronic address: marloes.huijbers@radboudumc.nl.
• J Affect Disord. 2015 Nov 15; 187: 54-61.

BackgroundMindfulness-based cognitive therapy (MBCT) and maintenance antidepressant medication (mADM) both reduce the risk of relapse in recurrent depression, but their combination has not been studied. Our aim was to investigate whether the addition of MBCT to mADM is a more effective prevention strategy than mADM alone.MethodsThis study is one of two multicenter randomised trials comparing the combination of MBCT and mADM to either intervention on its own. In the current trial, recurrently depressed patients in remission who had been using mADM for 6 months or longer (n=68), were randomly allocated to either MBCT+mADM (n=33) or mADM alone (n=35). Primary outcome was depressive relapse/recurrence within 15 months. Key secondary outcomes were time to relapse/recurrence and depression severity. Analyses were based on intention-to-treat.ResultsThere were no significant differences between the groups on any of the outcome measures.LimitationsThe current study included patients who had recovered from depression with mADM and who preferred the certainty of continuing medication to the possibility of participating in MBCT. Lower expectations of mindfulness in the current trial, compared with the parallel trial, may have caused selection bias. In addition, recruitment was hampered by the increasing availability of MBCT in the Netherlands, and even about a quarter of participants included in the trial who were allocated to the control group chose to get MBCT elsewhere.ConclusionsFor this selection of recurrently depressed patients in remission and using mADM for 6 months or longer, MBCT did not further reduce their risk for relapse/recurrence or their (residual) depressive symptoms.Copyright © 2015 Elsevier B.V. All rights reserved.

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