• Eur J Pain · Jan 2001

    Case Reports

    Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report.

    • C P Bleeker, R C Bremer, D A Dongelmans, R T van Dongen, and B J Crul.
    • Pain Clinic, Department of Anaesthesiology, University Hospital Nijmegen, 6500 HB Nijmegen, the Netherlands.
    • Eur J Pain. 2001 Jan 1; 5 (3): 325-9; discussion 329-31.

    AbstractPain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development. In this report the case of a 58-year-old female with neuropathic pain using increasing transdermal (TTS) fentanyl dosages to a maximum dose of 3400 microg/h resulting in fentanyl plasma levels of 173 ng/ml is described. For pain relief an epidural infusion at the level T1-2 with bupivacaine was started. Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness.Copyright 2001 European Federation of Chapters of the International Association for the study of Pain.

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