• Michael Pitta, Mark Zawadsky, Richard Verstraete, and Aaron Rubinstein.
• Department of Orthopedic Surgery, Medstar Georgetown University Hospital, Washington, DC.
• Transfusion. 2016 Feb 1; 56 (2): 466-71.

BackgroundTranexamic acid (TXA) has been reported to demonstrate efficacy in reducing blood loss during arthroplasty procedures.Study Design And MethodsThis study examines the effectiveness of TXA as a central element of a patient blood management program (PBMP) by evaluating blood loss and transfusion of red blood cells in three consecutive groups of patients undergoing routine total knee arthroplasty (TKA). Approximately 200 patients were in each group as follows: Group 1 was a control without TXA, Group 2 was intraarticular administration, and Group 3 was intravenous (IV) administration.ResultsThe IV group demonstrated a small but significant lower blood loss compared to the two other groups measured by hemoglobin (Hb) drift and nadir Hb levels. The routine use of TXA along with the other aspects of our PBMP provided significant cost savings due to the reduction in transfusions as well as a decrease in length of stay and has been an important element of our successful implementation of a PBMP.ConclusionThis study demonstrates a significant benefit from the routine use of TXA for total knee arthroplasty and is one of the first studies to demonstrate a small but significant benefit for IV administration in comparison to intraarticular administration. The routine use of TXA as a central element of a PBMP provides a cost savings and can help reduce the rate of transfusions for total knee arthroplasty.© 2015 AABB.

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