• Audrey Perrotin, de Flores Robin R INSERM, U1077, Caen, France. Université de Caen Basse-Normandie, UMR-S1077, Caen, Fran, Franck Lamberton, Géraldine Poisnel, La Joie Renaud R INSERM, U1077, Caen, France. Université de Caen Basse-Normandie, UMR-S1077, Caen, Franc, Vincent de la Sayette, Florence Mézenge, Clémence Tomadesso, Brigitte Landeau, Béatrice Desgranges, and Gaël Chételat.
• INSERM, U1077, Caen, France.
• J. Alzheimers Dis. 2015 Sep 24; 48 Suppl 1: S141-50.

BackgroundSubjective cognitive decline (SCD) may be the first clinical sign of Alzheimer's disease (AD). SCD individuals with normal cognition may already have significant hippocampal atrophy, a well-known feature of AD.ObjectiveTo test the hypothesis that SCD, compared to healthy individuals without SCD, have a pattern of hippocampal subfield atrophy similar to that measured in the AD pathology.Methods17 SCD, 21 AD, and 40 matched controls underwent a standard T1-weighted MRI and a dedicated high-resolution MRI proton-density hippocampal sequence. For each participant, three hippocampal regions-of-interest were manually delineated on the proton-density hippocampal sequence corresponding to the CA1, subiculum, and other (including CA2-3-4 and dentate gyrus) subfields. Total intracranial volume (TIV)-normalized subfield volumes were compared between-group. Voxelwise group comparisons assessed from the standard T1 MRI were also projected on 3D hippocampal surface views.ResultsBoth patient groups showed significant TIV-normalized volume decrease in hippocampus global volume and in CA1 and subiculum subfields as well as in the other subfield in AD compared to controls. Significant differences were observed between SCD and AD in hippocampus global TIV-normalized volume. Atrophy maps on hippocampal surface showed major involvement of the lateral part (CA1) in both SCD and AD, with larger overlap of other regions in AD.ConclusionThe findings indicate topographically similar hippocampal subfield changes in SCD individuals as those found in AD. This further highlights the relevance of SCD recruited from a memory clinic in assessing pre-dementia AD stages.

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