• J Neuroimaging · Sep 2016

    Comparative Study

    Ultrafast Brain MRI: Clinical Deployment and Comparison to Conventional Brain MRI at 3T.

    • Supada Prakkamakul, Thomas Witzel, Susie Huang, Daniel Boulter, Maria J Borja, Pamela Schaefer, Bruce Rosen, Keith Heberlein, Eva Ratai, Gilberto Gonzalez, and Otto Rapalino.
    • Neuroradiology Division, Department of Radiology, Massachusetts General Hospital, Boston, MA.
    • J Neuroimaging. 2016 Sep 1; 26 (5): 503-10.

    Background And PurposeTo compare an ultrafast brain magnetic resonance imaging (MRI) protocol to the conventional protocol in motion-prone inpatient clinical settings.MethodsThis retrospective study was HIPAA compliant and approved by the Institutional Review Board with waived inform consent. Fifty-nine inpatients (30 males, 29 females; mean age 55.1, range 23-93 years)who underwent 3-Tesla brain MRI using ultrafast and conventional protocols, both including five sequences, were included in the study. The total scan time for five ultrafast sequences was 4 minutes 59 seconds. The ideal conventional acquisition time was 10 minutes 32 seconds but the actual acquisition took 15-20 minutes. The average scan times for ultrafast localizers, T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR), diffusion-weighted, T2*-weighted sequences were 14, 41, 62, 96, 80, 6 seconds, respectively. Two blinded neuroradiologists independently assessed three aspects: (1) image quality, (2) gray-white matter (GM-WM) differentiation, and (3) diagnostic concordance for the detection of six clinically relevant imaging findings. Wilcoxon signed-rank test was used to compare image quality and GM-WM scores. Interobserver reproducibility was calculated.ResultsThe ultrafast T1-weighted sequence demonstrated significantly better image quality (P = .005) and GM-WM differentiation (P < .001) compared to the conventional sequence. There was high agreement (>85%) between both protocols for the detection of mass-like lesion, hemorrhage, diffusion restriction, WM FLAIR hyperintensities, subarachnoid FLAIR hyperintensities, and hydrocephalus.ConclusionsThe ultrafast protocol achieved at least comparable image quality and high diagnostic concordance compared to the conventional protocol. This fast protocol can be a viable option to replace the conventional protocol in motion-prone inpatient clinical settings.Copyright © 2016 by the American Society of Neuroimaging.

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