• Biochem. Biophys. Res. Commun. · Jan 1999

    Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases.

    • S Leder, Y Weber, X Altafaj, X Estivill, H G Joost, and W Becker.
    • Institut für Pharmakologie und Toxikologie, RWTH Aachen, Aachen, D-52057, Germany.
    • Biochem. Biophys. Res. Commun. 1999 Jan 19; 254 (2): 474-9.

    AbstractThe DYRK1A gene on human chromosome 21 encodes a protein kinase presumed to be involved in the pathogenesis of mental retardation in Down's syndrome. Here we describe a highly similar homolog, DYRK1B, which is, in contrast to DYRK1A, predominately expressed in muscle and testis. The human DYRK1B gene was mapped to chromosome 19 (19q12-13.11) by radiation hybrid analysis. The amino acid sequences of DYRK1A and DYRK1B are 84% identical in the N-terminus and the catalytic domain but show no extended sequence similarity in the C-terminal region. DYRK1B contains all motifs characteristic for the DYRK family of protein kinases. In addition, the sequence comprises a bipartite nuclear localization motif. A green fluorescent protein (GFP) fusion protein of DYRK1B was found mainly in the nucleus of transfected COS-7 cells. These data suggest that DYRK1B is a muscle- and testis-specific isoform of DYRK1A and is involved in the regulation of nuclear functions.Copyright 1999 Academic Press.

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