• Arq Neuropsiquiatr · Dec 2006

    Randomized Controlled Trial Comparative Study

    [Comparison of intravenous dipyrone to intravenous metoclopramide in the treatment of acute crisis of migraine: randomized clinical trial].

    • Sérgio Murilo Maciel Fernandes Filho, Márcio Santos Costa, Mariana Torres Fernandes, and Miriam Vils Foerster.
    • Setor de Emergência do Hospital Getúlio Vargas, Recife PE, Brasil (HGV). sergiomurilo@yahoo.com
    • Arq Neuropsiquiatr. 2006 Dec 1; 64 (4): 1005-8.

    IntroductionMigraine is one of the commonest diseases of clinical practice.Objective[corrected] To compare the analgesic effect of dipyrone to metoclopramide in the relief of pain.MethodWe conducted a pilot randomized study comparing intravenous dipyrone to intravenous metoclopramide in 27 patients presenting acute crisis of migraine. The primary end point was to compare reduction of intensity of pain up to 2 hours, as well as the development of collateral effects.ResultsThe groups had similar ages, but there were difference between the sexes. In men, metoclopramide reduced pain in 80.0% compared with 55.0% from dipyrone (p=0.052). In women, there was a reduction of 65.0% with metoclopramide and 71.2% with dipyrone (p=0.748). The small number of patients in the study might have influenced these results. Significant collateral effects were not found.ConclusionThere was no difference about the intensity of pain reduction neither about the development of collateral effects comparing dipyrone to metoclopramide.

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