• Chih-Cheng Chen, Chen-Chi Wang, Ching-Ping Wang, Tseng-Hsi Lin, Whe-Dar Lin, and Shih-An Liu.
• Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan.
• Otolaryngol Head Neck Surg. 2008 Jun 1; 138 (6): 762-7.

ObjectivesTo determine if tranexamic acid could reduce the drainage duration after head and neck procedures.Study DesignProspective, randomized, controlled trial.MethodsPatients who underwent head and neck operations were included. The study group was treated with tranexamic acid during the perioperative period whereas the control group received normal saline solution. Blood samples were also collected.ResultsThe study and control groups consisted of 26 and 29 patients, respectively. Although there was a significant difference in the drainage amount between the two groups, (49.7 vs 88.8 mL, P = 0.041), no significant difference could be found in the drainage duration between the two groups (2.69 vs 3.07 days, P = 0.146). There was also no significant difference in the coagulation profiles between the two groups.ConclusionWe did not find a meaningful effect in reducing the drainage duration after head and neck procedures with the use of prophylactic tranexamic acid.

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