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Stereotact Funct Neurosurg · Jan 2013
Case ReportsTransient global amnesia associated with accidental high-frequency stimulation of the right hippocampus in deep brain stimulation for segmental dystonia.
- Hansjörg Baezner, Christian Blahak, H Holger Capelle, Christoph Schrader, Götz Lütjens, and Joachim K Krauss.
- Department of Neurology, Universitaetsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.
- Stereotact Funct Neurosurg. 2013 Jan 1; 91 (5): 335-7.
AbstractWe report on a 66-year-old woman with segmental dystonia treated with chronic bilateral deep brain stimulation of the globus pallidus internus, in whom accidental high-voltage, high-frequency stimulation induced an episode of transient global amnesia (TGA) via an electrode contact which was misplaced in the right hippocampus. A possible mechanism underlying this TGA episode may have been the inhibition of local neuronal activity or fiber activation by high current density via direct electrical stimulation of hippocampal structures. While a unifying etiology of TGA has not been proven so far, our case demonstrates a possible link between focal electrical stimulation of hippocampal structures and the full clinical picture of the syndrome.Copyright © 2013 S. Karger AG, Basel.
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