• Br J Anaesth · Jul 1991

    Pharmacokinetic model driven infusion of propofol in children.

    • B Marsh, M White, N Morton, and G N Kenny.
    • Division of Anaesthetics, Glasgow Royal Infirmary.
    • Br J Anaesth. 1991 Jul 1; 67 (1): 414841-8.

    AbstractA computer controlled infusion device for propofol was used to induce and maintain general anaesthesia in 20 children undergoing minor surgical procedures. The device was programmed with an adult pharmacokinetic model for propofol. During and after anaesthesia, blood samples were taken for measurement of propofol concentrations and it was found that the values obtained were systematically overpredicted by the delivery system algorithm. New pharmacokinetic microconstants were derived from our data which reflected more accurately the elimination and distribution of propofol in a prospective study involving another 10 children.

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    This article appears in the collection: The 20 most cited pediatric anesthesia articles.

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    The 5th most cited pediatric anesthesia paper of all time, and 152nd overall with 329 citations.

    Daniel Jolley  Daniel Jolley
     
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